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What is the effect of cell network topology on the poro-elastic properties of bone?

Sunday (01.01.2040)
00:00 - 21:41
Part of:
- Poster The versatile usage of wrinkled surfaces 1 Bernhard Alexander Glatz
- Poster Penguin feather mimicking oil infused elastomer for anti-icing property 1 Dipl.-Ing. Nguyen Thanh-Binh
- Poster Radiation-based methods for surface modification of supramolecular peptide fibrils 0 Juhaina Bandak
- Poster Investigation of crack propagation of hierarchically structured ceramic materials on different length scales using bending tests 1 Cecilia Müller
- Poster Tobacco mosaic virus disks, preparation of samples to investigate mineralization by low voltage electron microscopy 1 Dr. Sabine Eiben
- Poster Deformation of Liquid-Liquid Phase Boundary as Template for Novel Surface Structured Polymer Particles and Coatings 1 Helena vom Stein
- Poster Sclerenchymatic tissue in Banksia follicles – The effect of moisture on dimensional and mechanical properties 1 Friedrich Reppe
- Poster Reconstructing in-situ nanofibrillar orientation and mechanics in arthropod cuticle using X-ray diffraction modelling 1 Ph.D. Yanhong Wang
- Poster Structural origins of morphing in plant tissues 1 Prof. Dr. Hanoch Daniel Wagner
- Poster What is the effect of cell network topology on the poro-elastic properties of bone? 1 Alexander van Tol
- Poster The fibrillar-level mechanisms of mutability in echinoderm connective tissue analysed using in situ synchrotron small-angle X-ray scattering 1 Dr. Himadri Shikhar Gupta
- Poster Growing bone-like tissues on negative Gaussian curvature surfaces 1 Prof. Dr. John Dunlop
- Poster Gradient porous materials for reliable structured adhesives 1 Ph.D. Di Tan
- Poster Transfer of surface properties of wheat leaves to technical surfaces 1 Miriam Huth
- Poster Damping Behaviour of Bioinspired and Natural Fibre Composites 1 Wilhelm Woigk
- Poster Cancer cells biomineralize ionic gold into nanoparticles-microplates via secreting defense proteins with specific gold-binding peptides 1 Dr. Ajay Vikram Singh
- Poster Microstructural Assessment of Calvarial Fusion in Mice of Different Ages and its Biomechanical Implications 1 Dr. Junning Chen
- Poster Diffusion-limited electroless silver reduction on copper for "porous monocrystal" 1 Dr. Nikolay Ryzhkov
- Poster Multiscale simulations of directed spider dragline silk self-assembly by flow 1 Dipl.-Ing. Ana Herrera
- Poster Inspirational Multiscale Natural Structures 1 Dr. XiaoMeng Sui
- Poster The Exoskeleton of Scorpions: from Structure to Mechanical Function 1 Israel Kellersztein
- Poster Investigating the multilayer fiber-reinforced structure of the wood cell using computer simulations and additive manufacturing 1 Laura Zorzetto
- Poster Light guided 3D-structuring of EPS produced by red algae 1 Moritz Klotz
- Poster Structural optimization of biopolymer composite Cottonid by variation of manufacturing parameters 1 Matthias Langhansl
- Poster Biomineralization of Materials made of Engineered Spider Silk Proteins 1 Vanessa Wicklein
- Poster Micro-Ikebana by Biomimetic Crystallization of Alkaline Earth Carbonates 1 Shota Kobayashi
- Poster Bioinspired hairy surfaces 0 Stefan Müllers
- Poster Reagent-free modification of bio-hydrogels by electron irradiation towards biomedical applications 1 Stefanie Riedel
- Poster Controlled Modification on Wood via SI-ATRP 1 Marta Vidiella del Blanco
- Poster Plant Biomimetics: Surface-Structured Pollen Particles and Transparent Flower Petals 1 Prof. Dr. Olaf Karthaus
- Poster Coupling of polymers to tobacco mosaic virus: towards the production of amphiphilic virus tubes 1 Dr. Sabine Eiben
- Poster Mechanical stable sulfobetainc Hydrogels - A candidate for biomedical application 1 Ramona Bianca Jasmin Ihlenburg
- Poster Structuring V2O5 Nanocomposites to Adapt the Sponge Spicules’ Architecture 1 Achim Diem
- Poster Fibers, Yarns and Non-Woven Meshes – Tough Morphologies Made of Recombinant Spider Silk Proteins 1 Fabian Müller
- Poster Recombinant Spider Silk-based Hybrid Materials for Advanced Energy Technology 1 Tamara Aigner
- Poster Bio-mediated materials syntheses 1 Dr. Daniel Van Opdenbosch
- Poster Design of Biomimetic Thin Coatings Composed of Cellulose Beta-Nanocrystals for Epitaxial Crystallization and Coassembly of 1D Nanoparticles 0 Dipl.-Ing. Zihao Lu
- Poster Seeded Mineralization Leads to Prismatic-Type CaCO3 Thin Coatings with Multiple Structural Functions 0 Ming Li
- Poster Multifunctional Layered Magnetic Composites 1 Christian Debus
- Poster Cuttlebone-inspired Structures for Mechanical Damping 1 Dipl.-Ing. Andrea Knöller

Session P.1: Poster discussion evening
Belongs to:
Session P: Poster Presentation

The microscopic porosity in bone forms a network-like structure which houses in its lacunae the cell bodies of osteocytes and in its canaliculi the long processes of these cells. It is thought that fluid flow through the canalicular network contributes to nutrition and mineral transport and to mechanotransduction by stimulating osteocytes due to shear forces. Poroelastic models have therefore been used to study the fluid flow through this network. However, these networks have a very heterogeneous topology [1] which has been neglected in these studies. We hypothesize that the network topology has a significant impact on fluid flow properties. The aim of our study was to use 3D imaging of actual networks and computational fluid flow analysis to perform a functional assessment of two common, but very different types of human osteons: 1) normal secondary osteons and 2) osteon-in-osteons, which consist of a newly formed smaller osteon within an existing parental osteon.

Confocal microscopy was used to image the osteocyte canalicular network in human osteons of both types. The 3D data was then translated into network models where the edges represented the canaliculi and nodes represented intersections of canaliculi (i.e. intersections of edges) and the lacunae [1]. Functional network analysis methods, inspired by the existing poro-elastic models of bone [2], were then used to simulate compression induced fluid flow and pressure patterns in the imaged networks.

Being based on real network topologies our analyses provide predictions of the variability of the fluid flow in human osteons. Although in both osteon types the network density is heterogeneous, only osteon-in-osteons show a particular heterogeneous network structure with a ring of low network connectivity. This ring is bridged by few canaliculi, leading to locally high fluid flow velocities and steep pressure gradients in osteon-in-osteons during dynamic loading of the bone. The network in the normal osteons is closely connected to the rest of the network, while the osteon-in-osteons have regions which are relatively isolated. This could be interpreted as a compromised nutrient transport. On the other hand, the locally higher fluid flow in osteon-in-osteons could result in higher mechanical shear forces and, therefore, a more efficient mechanotransduction compared to normal osteons. Our analysis suggests that different osteon types could contribute differently to the overall mechanosensitivity of bone.

Alexander van Tol
Max Planck Institute of Colloids and Interfaces
Additional Authors:
  • Dr. Junning Chen
    Max Planck Institute of Colloids and Interfaces
  • Dr. Andreas Roschger
    Max Planck Institute of Colloids and Interfaces
  • Dr. Felix Repp
    University of Würzburg
  • Dr. Paul Roschger
  • Prof. Dr. Peter Fratzl
    Max Planck Institute of Colloids and Interfaces
  • Dr. Richard Weinkamer
    Max Planck Institute of Colloids and Interfaces