In recent years the paradigm of implant-body interactions changed from minimization to the creation of bioactive or even degrading implant systems, based on ceramics, metals or polymers. Creating new implant types also calls for a refined understanding of the interactions and x-ray based methods lend themselves for this task as they provide a non-destructive means to probe a representative volume from the atomistic to the macroscopic scale. Biodegrading Magnesium implants received enormous attention and are slowly approaching first in men trials and commercial products. It is important to not only understand the degradation behaviour of the implant material but as well the reaction of the host body, the whereabouts of the degradation products and the nanostructural response over time.
In this talk, applications of advanced synchrotron methods such as x-ray absorption spectroscopy, X-ray diffraction tomography as well as scanning micro and nano diffraction, x-ray fluoresence and energy dispersive white beam diffraction on problems of implant degradation and bone mineralization will be presented. Particular attention will be given to novel tomographic techniques such as SAXS Tensor tomography and diffraction tomography with sub-micron resolution.
This system will be used to demonstrate how the combination of 2D and 3D scattering and fluorescence methods can help to understand the degradation process and enables the design of new, better matched implant materials.