4D Biofabrication by Shape-Morphing PolymersTuesday (20.03.2018) 12:00 - 12:20 Part of:
Most powerful technique for biofabrication – 3D printing still has certain limitations, which substantially restrict its broader use. These disadvantages are inability to achieve sufficient resolution and high-density cell printing, difficulty of fabrication of multicomponent and hollow structures, difficulty of orienting of cells and limited oxygen diffusion. We advanced design of biomaterials by developing 4D biofabrication approach using special polymers, which are able to change their shape – shape-morphing polymers. In particular, we developed a number of approaches for design of biocompatible shape-morphing polymeric objects using solid polymers and hydrogels, which are able to change their shape in response to such “biocompatible” stimuli as temperature and presence of calcium ions. We developed approaches for deposition of cells on and inside of shape-morphing polymeric objects. We have also demonstrated application of 4D biofabrication approach for controlled encapsulation of cells, design of porous scaffolds with controlled porosity and pore orientation, complex 3D cell patterning as well as fabrication of hydrogel-cell hollow structures.
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