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Radiation-based methods for surface modification of supramolecular peptide fibrils

Part of:
- Poster The versatile usage of wrinkled surfaces 1 Dr. Bernhard Alexander Glatz
- Poster Penguin feather mimicking oil infused elastomer for anti-icing property 1 Dipl.-Ing. Nguyen Thanh-Binh
- Poster Radiation-based methods for surface modification of supramolecular peptide fibrils 0 Juhaina Bandak
- Poster Investigation of crack propagation of hierarchically structured ceramic materials on different length scales using bending tests 1 Cecilia Müller
- Poster Tobacco mosaic virus disks, preparation of samples to investigate mineralization by low voltage electron microscopy 1 Dr. Sabine Eiben
- Poster Deformation of Liquid-Liquid Phase Boundary as Template for Novel Surface Structured Polymer Particles and Coatings 1 Helena vom Stein
- Poster Sclerenchymatic tissue in Banksia follicles – The effect of moisture on dimensional and mechanical properties 1 Friedrich Reppe
- Poster Reconstructing in-situ nanofibrillar orientation and mechanics in arthropod cuticle using X-ray diffraction modelling 1 Ph.D. Yanhong Wang
- Poster Structural origins of morphing in plant tissues 1 Prof. Dr. Hanoch Daniel Wagner
- Poster What is the effect of cell network topology on the poro-elastic properties of bone? 1 Alexander van Tol
- Poster The fibrillar-level mechanisms of mutability in echinoderm connective tissue analysed using in situ synchrotron small-angle X-ray scattering 1 Dr. Himadri Shikhar Gupta
- Poster Growing bone-like tissues on negative Gaussian curvature surfaces 1 Prof. Dr. John Dunlop
- Poster Gradient porous materials for reliable structured adhesives 1 Ph.D. Di Tan
- Poster Transfer of surface properties of wheat leaves to technical surfaces 1 Miriam Huth
- Poster Damping Behaviour of Bioinspired and Natural Fibre Composites 1 Wilhelm Woigk
- Poster Cancer cells biomineralize ionic gold into nanoparticles-microplates via secreting defense proteins with specific gold-binding peptides 1 Dr. Ajay Vikram Singh
- Poster Microstructural Assessment of Calvarial Fusion in Mice of Different Ages and its Biomechanical Implications 1 Dr. Junning Chen
- Poster Diffusion-limited electroless silver reduction on copper for "porous monocrystal" 1 Dr. Nikolay Ryzhkov
- Poster Multiscale simulations of directed spider dragline silk self-assembly by flow 1 Dipl.-Ing. Ana Herrera
- Poster Inspirational Multiscale Natural Structures 1 Dr. XiaoMeng Sui
- Poster The Exoskeleton of Scorpions: from Structure to Mechanical Function 1 Israel Kellersztein
- Poster Investigating the multilayer fiber-reinforced structure of the wood cell using computer simulations and additive manufacturing 1 Laura Zorzetto
- Poster Light guided 3D-structuring of EPS produced by red algae 1 Moritz Klotz
- Poster Structural optimization of biopolymer composite Cottonid by variation of manufacturing parameters 1 Matthias Langhansl
- Poster Biomineralization of Materials made of Engineered Spider Silk Proteins 1 Vanessa Wicklein
- Poster Micro-Ikebana by Biomimetic Crystallization of Alkaline Earth Carbonates 1 Shota Kobayashi
- Poster Bioinspired hairy surfaces 0 Stefan Müllers
- Poster Reagent-free modification of bio-hydrogels by electron irradiation towards biomedical applications 1 Stefanie Riedel
- Poster Controlled Modification on Wood via SI-ATRP 1 Marta Vidiella del Blanco
- Poster Plant Biomimetics: Surface-Structured Pollen Particles and Transparent Flower Petals 1 Prof. Dr. Olaf Karthaus
- Poster Coupling of polymers to tobacco mosaic virus: towards the production of amphiphilic virus tubes 1 Dr. Sabine Eiben
- Poster Mechanical stable sulfobetainc Hydrogels - A candidate for biomedical application 1 Ramona Bianca Jasmin Ihlenburg
- Poster Structuring V2O5 Nanocomposites to Adapt the Sponge Spicules’ Architecture 1 Achim Diem
- Poster Fibers, Yarns and Non-Woven Meshes – Tough Morphologies Made of Recombinant Spider Silk Proteins 1 Fabian Müller
- Poster Recombinant Spider Silk-based Hybrid Materials for Advanced Energy Technology 1 Tamara Aigner
- Poster Bio-mediated materials syntheses 1 Dr. Daniel Van Opdenbosch
- Poster Design of Biomimetic Thin Coatings Composed of Cellulose Beta-Nanocrystals for Epitaxial Crystallization and Coassembly of 1D Nanoparticles 0 Dipl.-Ing. Zihao Lu
- Poster Seeded Mineralization Leads to Prismatic-Type CaCO3 Thin Coatings with Multiple Structural Functions 0 Ming Li
- Poster Multifunctional Layered Magnetic Composites 1 Christian Debus
- Poster Cuttlebone-inspired Structures for Mechanical Damping 1 Dipl.-Ing. Andrea Knöller

Session P.1: Poster discussion evening
Belongs to:
Session P: Poster Presentation

Amyloid fibrils are polypeptide- or protein based supramolecules that are associated with serious diseases such as Alzheimer’s disease, type II diabetes or other misfolding disorders.[1] Despite the physiological shortcomings, the assemblage of polypeptides and even proteins to supramolecular fibrils is a popular method for the generation of functional nanostructures and hybrid nanomaterials suited for applications in optoelectronic devices, nanosensors and actuators.[2] The understanding of the molecular basis of the peptide monomer association process is the key to control fibrillation, which is necessary to develop potent modulators either in the medical or smart material field. It is well accepted that material surfaces influence the fibrillation process. For example, nanoparticles are considered as enhancers or suppressors.[3]

An alanine-scan of N-terminal modified NNFGAIL peptides was conducted in order to examine the influence of the substituted amino acid position on the fibrillation time by Thioflavin-assays and DLS and the morphology by SEM. Moreover, the influence of metallic nanoparticles with different sizes and surface modifications on the fibrillation process of the peptides was examined. In addition to these characterization studies, the applicability of templated metallic nanoparticles synthesized by reduction using VUV-excimer radiation and immobilized on peptide fibrils as an electrode material in solid acid fuel cells was investigated as well as plasma treatment of the nanoparticle-fibril-assemblies.[4, 5]

1. Caughey, B. and P.T. Lansbury, Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci, 2003. 26: p. 267-98.

2. Ardoña, H.A.M. and J.D. Tovar, Peptide π-Electron Conjugates: Organic Electronics for Biology? Bioconjugate Chemistry, 2015. 26(12): p. 2290-2302.

3. Cabaleiro-Lago, C., et al., Inhibition of IAPP and IAPP(20−29) Fibrillation by Polymeric Nanoparticles. Langmuir, 2010. 26(5): p. 3453-3461.

4. Zhou, B., et al., Platinum nanostructures via self-assembly of an amyloid-like peptide: a novel electrocatalyst for the oxygen reduction. Nanoscale, 2013. 5(7): p. 2669-73.

5. Wang, W., et al., Peptide-templated noble metal catalysts: syntheses and applications. Chem Sci, 2017. 8(5): p. 3310-3324.


Juhaina Bandak
Leibniz-Institut für Oberflächenmodifizierung e.V.
Additional Authors:
  • Dr. Christian Elsner
    Leibniz Institute of Surface Engineering (IOM)

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